Evidence for the Activation of 3-Methylcholanthrene as a Carcinogen in vivo and as a Mutagen in vitro by P1-450 from Inbred Strains of Mice
- 1 January 1975
- book chapter
- Published by Springer Nature
- Vol. 58 (00), 127-149
- https://doi.org/10.1007/978-1-4615-9026-2_9
Abstract
Genetic differences in aromatic hydrocarbon “responsiveness” exist among various mouse strains. New formation of cytochrome P1–450 and the induction of aryl hydrocarbon (benzo [a]pyrene) hydroxylase (as well as numerous other monooxygenase activities) appear to be associated ultimately with genes that cosegregate at a small number of genetic loci. By comparing “responsive” and “nonresponsive” siblings, we can evaluate the susceptibility of each individual to various mutagenic chemicals in vitro or carcinogenic agents in vivo.This publication has 28 references indexed in Scilit:
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