Relationship between the anti‐inflammatory and irritant properties of inflammatory exudate

Abstract

1 Using the rat paw oedema assay procedure a comparison was made between the anti-inflammatory and irritant properties of the inflammatory exudate obtained from polyester sponges implanted subcutaneously in adrenalectomized rats. Where necessary, comparison was also made with a known counter-irritant, carrageenin. 2 A significant correlation between the anti-inflammatory and irritant properties of sponge exudate was observed when each parameter was determined in relation to dose. A similar result was obtained with carrageenin. 3 A comparison of the two activities of sponge exudate samples harvested at various times following sponge implantation did not give a significant correlation although in each case significant anti-inflammatory activity was accompanied by marked irritation. 4 Time-effect curves of the two activities of sponge exudate showed a significant correlation over the time period examined. However, no such correlation was obtained using carrageenin. 5 Both activities of sponge exudate were retained following dialysis. 6 These findings are discussed in relation to a counter-irritant mode of action for sponge exudate.