On the interaction of drugs with the cholinergic nervous system
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 56 (1), 37-40
- https://doi.org/10.1007/bf00571405
Abstract
A symmetrical cross-tolerance was found between two phencyclidine derivatives-phencyclidine and cyclohexamine-and also between two cholinergic drugs-physostigmine and oxotremorine. On the other hand, mice rendered tolerant to the phencyclidine derivatives showed cross-tolerance to these cholinergic drugs, but no cross-tolerance was observed in the opposite direction. The applicability of such experiments to the elucidation of neurochemical interactions of centrally acting drugs is discussed.Keywords
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