THE ANXIOGENIC ACTION OF FG-7142 IN THE SOCIAL-INTERACTION TEST IS REVERSED BY CHLORDIAZEPOXIDE AND RO-15-1788 BUT NOT BY CGS-8216
- 1 January 1984
- journal article
- research article
- Vol. 271 (2), 198-205
Abstract
FG 7142 effects were examined in the social interaction test, alone and in combination with chlordiazepoxide, Ro 15-1788 and CGS 8216. FG 7142 (5 mg/kg) anxiogenic action was reversed by chlordiazepoxide (5 mg/kg) and by Ro 15-1788 (10 mg/kg), but not by CGS 8216 (10 mg/kg). FG 7142 profile in this test and its interaction patterns with other compounds is similar to 3-carboethoxy-.beta.-carboline, but can be distinguished from Ro 15-1788 and CGS 8216. FG 7142, Ro 15-1788 and CGS 8216 may act via different sites to produce their anxiogenic effects.This publication has 9 references indexed in Scilit:
- Intracranial self-stimulation distinguishes between two benzodiazepine antagonistsNeuroscience Letters, 1984
- DMCM: A potent convulsive benzodiazepine receptor ligandEuropean Journal of Pharmacology, 1983
- Interactions of ethyl-β-carboline-3-carboxylate and Ro 15-1788 with CGS 8216 in an animal model of anxietyNeuroscience Letters, 1983
- Audiogenic seizures in DBA/2 mice discriminate sensitively between low efficacy benzodazepine receptor agonists and inverse agonistsLife Sciences, 1983
- 3-carboethoxy-β-carboline (β-CCE) elicits electroencephalographic seizures in rats: Reversal by the benzodiazepine antagonist CGS 8216Life Sciences, 1983
- beta-Carbolines enhance shock-induced suppression of drinking in rats.Proceedings of the National Academy of Sciences, 1983
- Quinolines and anxiety: Anxiogenic effects of CGS 8216 and partial anxiolytic profile of PK 9084Pharmacology Biochemistry and Behavior, 1983
- The anxiogenic action of benzodiazepine antagonistsNeuropharmacology, 1982
- Selective antagonists of benzodiazepinesNature, 1981