Experimental Production of Kidney Stones With Urea-Splitting Organisms

Abstract

In view of the importance of infection in kidney stone formation, the effect of urea-splitting organisms on the formation of calculi was studied. Rabbits were injected intraven. with organisms recovered from the urine of patients suffering from Ca phosphate urinary calculi. The animals, following the infection, voided a markedly alkaline urine for 12-24 hrs.; later the urine became normal and acid. When an artificial hydronephrosis was produced in rabbits and urea-splitting organisms subsequently injected, renal calculi developed.