WIRKUNG VON SULFONYLHARNSTOFFVERBINDUNGEN AUF DIE MITOSENFREQUENZ DER INSULÄREN B-ZELLEN

Abstract

It is shown that the sulphonylureas BZ 55 and D 860 are able to increase the number of mitoses of beta cells in the pancreatic islets which have previously been checked by colchicine. The effect of D 860 is 8 to 10 times larger and the effect of BZ 55 2 to 4 times larger than the normal one. These results are ascribed to the stimulated beta cell system. They are considered to be a further proof of the theory that these substances possess an increasing effect on the production and secretion of insulin. This corresponds to the fact that cortisone or glucose are also increasing the frequency of mitoses in beta cells.