Comparison of Norepinephrine Release in Hypertensive Rats: I Hypothalamic and Brainstem Tissues
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Clinical and Experimental Hypertension. Part A: Theory and Practice
- Vol. 8 (2), 201-219
- https://doi.org/10.3109/10641968609074772
Abstract
Stimulation induced 3H-norepinephrine release was measured in hypothalamus and brainstem of spontaneously hypertensive (SHR) and normotensive (WKY) rats. Age dependent changes in 3H-norepinephrine release were shown to occur in the anterior and posterior hypothalamus and the A2 region of the nucleus tractus solitarius (NTS). In an attempt to determine whether these changes in 3H-trasmitter release were causal or merely secondary to the increase in blood pressure, similar release studies were carried out in DOCA-salt and one kidney-one clip hypertensive animals with similar levels of systolic blood pressure. The changes in stimulus-induced 3H-norepinephrine release seen in the SHR were not observed in the other two models of hypertension, suggesting that one: they were not secondary to an increase in systolic blood pressure; and two that the changes observed in the SHR may possibly play a role in the development and/or maintenance of the hypertension.Keywords
This publication has 33 references indexed in Scilit:
- Effect of Sodium Depletion on the Release of [3H]Norepinephrine from Central and Peripheral Tissue of Wistar-Kyoto and Spontaneously Hypertensive RatsJournal of Cardiovascular Pharmacology, 1985
- Angiotensin Facilitation of Noradrenergic Neurotransmission in Central Tissues of the RatJournal of Cardiovascular Pharmacology, 1984
- Noradrenergic transmission in the isolated portal vein of the spontaneously hypertensive rat.Hypertension, 1984
- Peripheral neurogenic factors in acute and chronic alterations of arterial pressure.Circulation Research, 1983
- The release of endogenous norepinephrine from the coccygeal artery of spontaneously hypertensive and Wistar-Kyoto rats.Circulation Research, 1982
- Neural Mechanisms in HypertensionAnnual Review of Physiology, 1980
- Central nervous regulation of vascular resistance.Annual Review of Physiology, 1980
- Effect of phenylethanolamine N-methyltransferase and dopamine-β-hydroxylase inhibition on epinephrine levels in the brainLife Sciences, 1977
- Production of Hypertension with Desoxycorticosterone Acetate-Impregnated Silicone Rubber ImplantsJournal of Pharmaceutical Sciences, 1973
- Central adrenergic neurones and the initiation and development of experimental hypertensionCellular and Molecular Life Sciences, 1972