Transposon‐like Correia elements: structure, distribution and genetic exchange between pathogenic Neisseria sp
Open Access
- 5 June 2002
- journal article
- Published by Wiley in FEBS Letters
- Vol. 522 (1-3), 52-58
- https://doi.org/10.1016/s0014-5793(02)02882-x
Abstract
Correia elements are a prominent feature of all four Neisseria genome sequences. We report an in silico analysis of the structure and genomic distribution of these elements and some preliminary biochemical data. Correia elements fall into four major families, distinguished by a 50 bp internal deletion and five point mutations. The elements resemble a transposon with 25 bp inverted repeats and a TA duplication at the target site. Within the element there is a functional integration host factor binding site. The genomic distribution of Correia elements is essentially random except for some small Correia‐less regions apparently acquired by horizontal transfer. Phylogenetic analysis suggests that their presence predates the divergence of Neisseria meningitidis and Neisseria gonorrhoeae.Keywords
This publication has 22 references indexed in Scilit:
- Whole-genome organization and functional properties of miniature DNA insertion sequences conserved in pathogenic NeisseriaeGene, 2001
- Recombination and the Population Structures of Bacterial PathogensAnnual Review of Microbiology, 2001
- Protein–DNA contacts and conformational changes in the Tn10 transpososome during assembly and activation for cleavageThe EMBO Journal, 2001
- DNA circle formation in Neisseria gonorrhoeae: a possible intermediate in diverse genomic recombination processesMolecular Genetics and Genomics, 2001
- Finding pathogenicity islands and gene transfer events in genome dataBioinformatics, 2000
- Molecular models accounting for the gene conversion reactions mediating gonococcal pilin antigenic variationMolecular Microbiology, 2000
- Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491Nature, 2000
- Complete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58Science, 2000
- Transcriptional activation by protein-induced DNA bending: evidence for a DNA structural transmission model.Proceedings of the National Academy of Sciences, 1996
- Three promoters near the termini of IS10: pIN, pOUT, and pIIICell, 1983