Morphine hyperthermia in the rat: its attenuation by physostigmine
Open Access
- 1 March 1972
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 44 (3), 544-548
- https://doi.org/10.1111/j.1476-5381.1972.tb07291.x
Abstract
1 In rats, a subcutaneous injection of morphine (2·5 mg/kg) produced hyperthermia which was greatly attenuated by an intraperitoneal injection of physostigmine (0·1 mg/kg), but not of neostigmine (0·08 mg/kg) and promptly reversed by a subcutaneous injection of nalorphine. 2 It is concluded that the hyperthermia is a specific response to morphine, central in origin, and the result of diminished acetylcholine (ACh) release from central cholinergic neurones.Keywords
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