Effect of Cardiac Drugs on the Phosphorylated Intermediates of the Rat.

Abstract

Investigations were made to measure the concn. of a number of phosphorylated intermediates of glycolysis of the rat under various conditions of treatment with digitoxin. There was no marked difference in the distribution of acid-soluble phosphorylated intermediates of glycolysis in the heart muscle of normal and digitoxin-poisoned rats. Small differences in the glycogen values of heart values were noted, but there was an increased amt. of liver glycogen in the digitalized animals as compared with the controls as indicated by an avg. of 2.39% of glycogen in the former and 1.85% in the liver of the latter. There was no difference in the rate of breakdown of glycogen in the excised liver tissue in normal and digitoxin-treated rats. Increased glycogenesis occurred in the liver of rats given non-toxic doses of digitoxin while toxic doses of the drug resulted in a decrease in the amt. of liver glycogen in rats in which symptoms of over-digitalization were manifested.