Fcγ receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor
- 28 March 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 342 (1), 15-18
- https://doi.org/10.1016/0014-5793(94)80575-x
Abstract
We report that activation of phospholipase C (PLC) by cross-linking of the platelet low-affinity Fcγ receptor II (Fcγ RII) is inhibited by two structurally distinct tyrosine kinase inhibitors, staurosporine and ST271. This contrasts with PLC activation induced by thrombin and U46619, a thromboxane mimetic, whose receptors have seven transmembrane domains characteristic of G-protein coupled receptors. Several proteins undergo phosphorylation on tyrosine on FcγRII cross-linking upstream of protein kinase C (PKC), Ca2+ and aggregation, including the FcγRII itself. The role of FcγRII phosphorylation in the regulation of PLC is discussedKeywords
This publication has 17 references indexed in Scilit:
- Differential expression of Fcγ RIIA, Fcγ RIIB and Fcγ RIIC in hematopoietic cells: Analysis of transcriptsMolecular Immunology, 1993
- Wheat Germ Agglutinin-Induced Intracellular Calcium Mobilization in Human Platelets: Suppression by Staurosporine and Resistance to Cyclic AMP InhibitionBiochemical and Biophysical Research Communications, 1993
- SH2 domains recognize specific phosphopeptide sequencesCell, 1993
- Activation of human platelets by peroxovanadate is associated with tyrosine phosphorylation of phospholipase Cγ and formation of inositol phosphatesBiochemical Journal, 1993
- Effects of tyrosine kinase inhibitors on protein kinase‐independent systemsFEBS Letters, 1993
- Protein-tyrosine kinase p72syk is activated by wheat germ agglutinin in plateletsBiochemical and Biophysical Research Communications, 1992
- Tyrosine phosphorylation of phospholipase C-gamma 1 induced by cross-linking of the high-affinity or low-affinity Fc receptor for IgG in U937 cells.Proceedings of the National Academy of Sciences, 1992
- Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.Proceedings of the National Academy of Sciences, 1989
- Human platelet Fc receptor for immunoglobulin G. Identification as a 40,000-molecular-weight membrane protein shared by monocytes.Journal of Clinical Investigation, 1985
- 1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis.Proceedings of the National Academy of Sciences, 1985