Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance
- 20 November 2007
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 51 (2), 328-335
- https://doi.org/10.1007/s00125-007-0876-9
Abstract
Fatty acid desaturases introduce double bonds into growing fatty acid chains. The key desaturases in humans are Δ5-desaturase (D5D), Δ6-desaturase (D6D) and stearoyl-CoA desaturase (SCD). Animal and human data implicate hepatic desaturase activities in insulin resistance, obesity and dyslipidaemia. However, the role of desaturase activity in adipose tissue is uncertain. We therefore evaluated relationships between adipose mRNA expression, estimated desaturase activities (fatty acid ratios) in adipose tissue and insulin resistance.Keywords
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