Transferrin and HLA: Spontaneous Abortion, Neural Tube Defects, and Natural Selection
- 10 October 1985
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 313 (15), 925-932
- https://doi.org/10.1056/nejm198510103131505
Abstract
We report evidence that transferrin C3, a gene present in 9 to 10 per cent of whites, is associated with recurrent spontaneous abortion (P = 0.001) and that maternal transferrin genotype has an effect on the transmission ratio of the common transferrin genes (C1, C2, and C3) from heterozygous fathers to normal offspring (P<0.002). The effect of maternal genotype on paternal gene transmission is an unusual example of the operation of selection in the human reproductive process. This effect, together with the separate evidence for association of the transferrin C3 allele with spontaneous abortion, indicates that transferrin is a second marker (in addition to HLA) of genes important in reproduction.This publication has 30 references indexed in Scilit:
- Neural tube defects in Eastern Ontario and Western Quebec: Demography and family dataAmerican Journal of Medical Genetics, 1984
- Completion of mouse embryogenesis requires both the maternal and paternal genomesCell, 1984
- Central nervous system malformations in the Kraków region. II. Case control studies on the human leukocyte antigen genotype and haplotype frequenciessAmerican Journal of Medical Genetics, 1984
- Ferrtin secretion by human mononuclear cells: Association with HLA phenotypeClinical Immunology and Immunopathology, 1983
- The immunoregulatory nature of ironCellular Immunology, 1983
- Distribution of Transferrin (Tf) Subtypes in Asian, Pacific and Australian Aboriginal Populations: Evidence for the Existence of a New Subtype Tfc6Human Heredity, 1983
- Genetic mapping of the hemochromatosis locus on chromosome sixHuman Immunology, 1980
- Disturbed segregation at the transferrin locus of the deer mouseGenetics Research, 1970
- Evidence for the Tf locus being associated with an early lethal factor in a strain of pigsAnimal Blood Groups and Biochemical Genetics, 1970
- THE COMBINATION OF PROBABILITIES ARISING FROM DATA IN DISCRETE DISTRIBUTIONSBiometrika, 1949