Pre‐ and postnatal growth and protein turnover in four muscles of the rat
- 1 March 1984
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 7 (3), 235-242
- https://doi.org/10.1002/mus.880070309
Abstract
Developmental growth and associated changes in protein turnover and nucleic acid concentrations have been studied in four individual skeletal muscles. They have also been related to changes in the whole animal. The growth rates of both fast and slow muscle types progressively diminished from the fetus to old age. Similarly, the fractional rates of protein synthesis (measured in vivo) and breakdown in each muscle type declined with age; the changes in the former correlating with decreases in the ribosomal capacities of the muscles. Throughout, fast muscles possessed lower turnover rates. The mean half-lives of mixed proteins were 12.0, 14.4, 13.5, and 7.2 days in the extensor digitorum longus (EDL), gastrocnemius, diaphragm, and soleus muscles, respectively, 310 days postpartum. Muscle atrophy was found at 735 days, at which stage the decreased protein synthetic rate in the soleus was due to a fall in the ribosomal capacity, while that in the EDL was attributable to a decreased synthetic rate per ribosome.This publication has 24 references indexed in Scilit:
- Pre- and post-natal growth and protein turnover in smooth muscle, heart and slow- and fast-twitch skeletal muscles of the ratBiochemical Journal, 1984
- Contractile protein isozymes in muscle development: identification of an embryonic form of myosin heavy chain.Proceedings of the National Academy of Sciences, 1979
- Distribution of myosin isoenzymes among skeletal muscle fiber types.The Journal of cell biology, 1979
- METHODS FOR DETERMINING PROTEIN TURNOVERPublished by Elsevier ,1979
- Thyroidal trophic influence on skeletal muscle myosinNature, 1977
- Biochemical and Histochemical Changes in Energy Supply-Enzyme Pattern of Muscles of the Rat during Old AgeGerontology, 1975
- The Role of Skeletal and Cardiac Muscle in the Regulation of Protein MetabolismPublished by Elsevier ,1970
- The effect of senility on skeletal muscles in the mouseExperimental Gerontology, 1969
- Protein Metabolism during Growth and DevelopmentPublished by Elsevier ,1969
- Differentiation of fast and slow muscles in the cat hind limbThe Journal of Physiology, 1960