Acetylcholine. 2. The heat of hydrolysis

Abstract

Values of [DELTA] H0298 were measured for the alkaline hydrolysis of acetylcholine bromide and related substances. These lead to small values for the neutral hydrolysis, similar to those found for ordinary esters, in contrast to the high values characteristic of creatine phosphate hydrolysis. There will be a loss of free energy of about 14,000 cal. in a postulated synthesis of acetylcholine starting from creatine phosphate.