A Surface Antigen Marker for Human Monocytes

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Abstract
Antisera have been raised in rabbits against human peritoneal macrophages. After absorption with tonsil cells the sera reacted, by direct and indirect immunofluorescence, with phagocytic mononuclear cells from a variety of tissues and, in addition, stained a small population of nonphagocytic non-T, non-B mononuclear cells present in blood, spleen, and marrow but absent or very rare in tonsil and thymus. The antisera may define a human monocyte-macrophage cell surface differentiation antigen (HuMA) and can be used to deplete or enrich reactive cell populations.