Effect of Aliphatic Oxime and Isatin Thiosemicarbazones on Vaccinia Infection in the Mouse and in the Rabbit

Abstract

Mice inoculated intracerebrally with vaccinia virus and treated with certain thiosemicarbazones containing either benzene or heterocyclic groups are protected against the virus. These materials are effective either when admn. parenterally or fed in the diet. The concns. of virus in brains of mice treated with isatin thiosemicarbazone (T. S.) and sacrificed 5 days after initiation of infection were not significantly different from those present in untreated animals. Serial passage of the virus intracer. in mice treated with isatin T. S. resulted in a gradual diminution in the amt. of virus demonstrable in the brain. Treatment with isatin T. S. failed to protect rabbits inoculated intracer. with vaccinia virus. Certain aliphatic oxime thiosemicarbazones were as effective as benzene or heterocyclic derivatives as chemoprophylactic agents against vaccinia virus in mice.