Urine Fibrinogen Fragments in Human Renal Allografts

Abstract

Nineteen patients excreted fibrinogen fragments D and E in their urine at specific times after renal transplantation. Sixteen patients studied within two weeks after transplantation all excreted the fragments. The fragments were absent in 62 specimens from 15 patients without rejection more than two weeks after transplantation. In four reversible, and in three irreversible rejections, the fragments reappeared. They disappeared after intensified immunosuppressive therapy in the reversible and persisted in the irreversible rejections. One allograft from a patient with bad recurrent glomerulonephritis and five patients with other renal diseases also excreted the fragments. Corresponding serum did not contain the fragments.