Detection of Mutagenicity of the Colon Carcinogen 1,2-Dimethylhydrazine by the Host-Mediated Assay and Its Correlation to Carcinogenicity
- 1 August 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 61 (2), 457-460
- https://doi.org/10.1093/jnci/61.2.457
Abstract
Mutagenic potential of 1,2-dimethylhydrazine (DMH) was investigated in the host-mediated assay with mice used as hosts. This assay revealed potent mutagenicity of this colon carcinogen for Salmonella typhlmurium G46. The mutagenicity of DMH was inhibited by pretreatment of mice with disulfiram. In addition, mouse strain and sex differences influenced the mutation induction by DMH: Mutation induction was significantly lower in C57BL/6 mice than in outbred ICR mice of either sex and was generally higher in male mice than in females of either C57BL/6 or ICR mice.Keywords
This publication has 4 references indexed in Scilit:
- GENETICS OF COLON CARCINOGENESIS IN MICE TREATED WITH 1,2-DIMETHYLHYDRAZINE1977
- Detection and Estimation of Azomethane in Expired Air of l,2-Dimethylhydrazine-Treated Rats2JNCI Journal of the National Cancer Institute, 1976
- Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion.Proceedings of the National Academy of Sciences, 1976
- Mutagenicity of Cycasin Aglycone (Methylazoxymethanol), a Naturally Occurring CarcinogenScience, 1966