Intestinal Malabsorption and Immunoglobulin Deficiency
- 1 January 1971
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Internal Medicine
- Vol. 127 (1), 141-147
- https://doi.org/10.1001/archinte.1971.00310130145027
Abstract
Available evidence suggests that hypogammaglobulinemia, particularly immunoglobulin A (IgA) deficiency, may be associated with intestinal malabsorption and mild to moderate villous atrophy of the proximal jejunal mucosa.1-3 We have encountered such a patient who responded favorably in turn to a gluten-free diet and to tetracycline hydrochloride therapy administered orally. The purpose of this report is to relate the clinical and immunological findings in this case to published data from other patients with malabsorption and documented immunoglobulin deficiencies. Methods For Special Studies The serological and tissue techniques, as well as the method used to quantify mucosal lymphoid cells employing cell density indices (CDI), have been reported.4 The CDI are arbitrary units which represent cells per unit area of interstitium.4 In the previous study of eight specimens of normal human rectal mucosa, the CDI (mean ± SE of the mean) for IgA-, IgM- and IgG-containing lymphoid cells were 80.14This publication has 8 references indexed in Scilit:
- TROPICAL SPRUE IN EXPATRIATES FROM THE TROPICS LIVING IN THE CONTINENTAL UNITED STATESMedicine, 1969
- SERUM-IMMUNOGLOBULINS IN ADULT CŒLIAC DISEASEThe Lancet, 1969
- IgA absence associated with short arm deletion of chromosome No. 18The Journal of Pediatrics, 1969
- IMMUNOGLOBULINS IN SERUM AND JEJUNAL BIOPSIES IN NON‐TROPICAL SPRUEActa Medica Scandinavica, 1969
- Dysgammaglobulinaemia in Tropical SprueBMJ, 1968
- Severe Diarrhea Controlled by Gamma Globulin in a Patient with Agammaglobulinemia, Amyloidosis, and ThymomaAnnals of Internal Medicine, 1966
- Lack of gamma A-immunoglobulin in serum of patients with steatorrhoea.Gut, 1966
- IMMUNOGLOBULIN LEVELS FROM THE NEWBORN PERIOD TO ADULTHOOD AND IN IMMUNOGLOBULIN DEFICIENCY STATES*JCI Insight, 1962