Regional myocardial oxygen tension: 19F MRI of sequestered perfluorocarbon
- 1 June 1996
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 35 (6), 827-833
- https://doi.org/10.1002/mrm.1910350607
Abstract
A novel noninvasive method of measuring local myocardial oxygen tension (pO2) In the perfused rat heart using 19F MRI is demonstrated. Tissue pO2 was determined on the basis of the 19F spin-lattice relaxation rate (R1) of perflubron (perfluorooctyl bromide) sequestered in the heart after IV infusion of an emulsion. Spectroscopic measurement of R1 was previously used to measure a global weighted average of oxygen status. 19F MRI now provides 3D spatial resolution indicating local cardiac pO2 under normally perfused, globally ischemic, and regionally ischemic conditions.Keywords
This publication has 25 references indexed in Scilit:
- Rapid tissue oxygen tension mapping using 19F inversion‐recovery echo‐planar imaging of P erfluoro‐15 ‐crown‐5‐etherMagnetic Resonance in Medicine, 1994
- Imaging oxygen tension in liver and spleen by 19F NMRMagnetic Resonance in Medicine, 1993
- In vivo oxygen tension and temperature: Simultaneous determination using 19F NMR spectroscopy of perfluorocarbonMagnetic Resonance in Medicine, 1993
- Fast perfluorocarbon imaging using 19F U‐FLAREMagnetic Resonance in Medicine, 1993
- 1H-NMR characterization of the human myocardium myoglobin and erythrocyte hemoglobin signaisBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1993
- Effect of homonuclear J modulation on 19F spin‐echo imagesMagnetic Resonance in Medicine, 1991
- In Vivo Measurements of Vascular Oxygen Tension in Tumors Using MRI of a Fluorinated Blood SubstituteInvestigative Radiology, 1989
- 19F NMR imaging of blood oxygenation in the brainMagnetic Resonance in Medicine, 1988
- Biochemical mechanisms of acute contractile failure in the hypoxic rat heartCardiovascular Research, 1986
- The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs.Circulation, 1977