The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis
Open Access
- 18 April 2007
- journal article
- Published by Springer Nature in Arthritis Research & Therapy
- Vol. 9 (2), R40
- https://doi.org/10.1186/ar2179
Abstract
An important feature of autoimmune diseases is the overlap of pathophysiological characteristics. Clustering of autoimmune diseases in families suggests that genetic variants may contribute to autoimmunity. The aim of the present study was to investigate the role of the interferon induced with helicase domain 1 (IFIH1) A946T (rs1990760 A>G) variant in rheumatoid arthritis (RA), as this was recently associated with susceptibility to type 1 diabetes. A total of 965 Caucasians with RA and 988 healthy controls were genotyped for IFIH1 A946T. Gene expression of IFIH1 was measured in peripheral blood leukocytes using real-time PCR. Genotypes were equally distributed in both RA cases and healthy controls (odds ratio for allele C = 0.9, 95% confidence interval = 0.8–1.0, P = 0.3). No association was detected after stratification by sex, age at onset, rheumatoid factor status, anti-cyclic citrullinated peptide status or radiological joint damage. Levels of IFIH1 mRNA were approximately twofold higher in blood leucocytes of RA cases compared with healthy controls (P < 0.0001). These results indicate that the IFIH1 is upregulated in RA but that the A946T variant does not contribute significantly to the genetic background of RA.Keywords
This publication has 23 references indexed in Scilit:
- Independent associations of anti-cyclic citrullinated peptide antibodies and rheumatoid factor with radiographic severity of rheumatoid arthritisArthritis Research & Therapy, 2006
- Regression Mapping of Association between the Human Leukocyte Antigen Region and Graves DiseaseAmerican Journal of Human Genetics, 2005
- A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetesNature Genetics, 2004
- Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune diseaseNature, 2003
- The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locusHuman Molecular Genetics, 1999
- Familial clustering of rheumatoid arthritis with other autoimmune diseasesHuman Genetics, 1998
- Genetic Analysis of Autoimmune DiseaseCell, 1996
- Genetic analysis of HLA class II alleles and susceptibility to Type 1 (insulin-dependent) diabetes mellitus in Japanese subjectsDiabetologia, 1992
- GENETIC INTERRELATIONSHIP BETWEEN INSULIN-DEPENDENT DIABETES-MELLITUS, THE AUTOIMMUNE THYROID-DISEASES, AND RHEUMATOID-ARTHRITIS1986
- Mixed lymphocyte cultures in rheumatoid arthritis.JCI Insight, 1976