Feasibility of a Low Dosage Dynamic Powder Dispenser for Drug Delivery to the Lungs

Abstract

Inhalation of drugs offers the opportunity to treat diseases of the respiratory tract. A manually operated prototype, called Dynamic Powder Dispenser (DPD), for dispensing a predetermined amount of powdered drug has been developed. This device actively disperses powder from a chamber through a mouthpiece ready for inhalation. The DPD is a multi-single dose device which delivers drugs actively and does not require breath actuation. This DPD which insufflates dry powder into the respiratory tract can be considered as a counterpart to an MDI. The respirable fraction was found in-vitro in the range of 10% and 25% for salbutamol and terbutaline, respectively.