Effects of pneumococcal mucopeptide and capsular polysaccharide on phagocytosis

Abstract

Pneumoccal cell wall and capsular products from eight serotypes were tested for their ability to inhibit polymorphonuclear neutrophil killing of the same eight pneumococcal strains. Crude pneumococcal cell wall preparations from all serotypes inhibited phagocytic killing of several pneumococcal serotypes, and were just as effective with heterologous as with homologous strains. Phagocytosis dependent on heat-labile serum factors was inhibited, whereas phagocytosis not dependent on heat-labile factors was not significantly affected. These findings were compatible with inhibition of complement consumption. The inhibitory activity was found in a purified cell wall mucopeptide, whereas purified capsular polysaccharides failed to inhibit phagocytosis.