Comparative Pharmacology of Cefaclor and Cephalexin
Open Access
- 1 August 1977
- journal article
- clinical trial
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 12 (2), 157-162
- https://doi.org/10.1128/aac.12.2.157
Abstract
Two cephalosporin antibiotics, cefaclor and cephalexin, were administered orally to healthy, adult male volunteers for comparison of their pharmacological properties. In doses of 250 mg orally, cefaclor produced a peak serum concentration of 6.01 ± 0.55 (standard deviation [SD]) μg/ml compared with 9.43 ± 2.36 μg/ml for cephalexin ( P < 0.01). The half-lives were 0.58 ± 0.07 (SD) h and 0.80 ± 0.12 (SD) h, and elimination constants were 1.22 ± 0.15 and 0.88 ± 0.13 h −1 for cefaclor and cephalexin, respectively ( P < 0.001). Neither drug showed accumulation over the dosing period, and both were well tolerated.Keywords
This publication has 4 references indexed in Scilit:
- In Vitro Susceptibility Studies with Cefaclor and CephalexinAntimicrobial Agents and Chemotherapy, 1977
- Metabolism of [ 14 C]Cefaclor, a Cephalosporin Antibiotic, in Three Species of Laboratory AnimalsAntimicrobial Agents and Chemotherapy, 1976
- Pharmacokinetics and Clinical Use of Cephalosporin AntibioticsJournal of Pharmaceutical Sciences, 1975
- The Cephalosporin Group of AntibioticsPublished by Elsevier ,1975