FURTHER CHARACTERIZATION OF NATURAL KILLER CELLS INDUCED BY KUNJIN VIRUS

Abstract

The natural killer (NK)^* cell induced one to two days after Kunjin virus infection of BAI.B/c mice is cytotoxic for a wide range of syngeneic, allogeneic and xenogeneic cell lines. It is also weakly cytotoxic for some non-malignant cells including mouse fibroblasts, macrophages and thymocytes, but not lymph node cells. Levels of lysis of non-tumour target cells are dependent on their genotype. Furthermore, malignant cell lines may become resistant following transplantation in vivo then susceptible again after culture in vitro. The virus-induced NK cell is elicited as readily in athymic (nude) as in normal mice. X-irradiation inhibits its development if administered prior to infection. It is labile on culture at 37°. The cell carries Fc receptors but its NK activity is not antibody-dependent.