DNA-Catalyzed Polymerization
- 12 January 2002
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 124 (5), 746-747
- https://doi.org/10.1021/ja017319j
Abstract
Native DNA oligomers are shown to be stereoselective catalysts for the polymerization of 5'-amino-3'-acetaldehyde-modified thymidine/adenosine nucleosides through reductive amination. The reaction follows step-growth kinetics to read the encoded sequence and chain-length information in the antiparallel direction. Single mismatches in the template are selected against at a level of >100:1. A method is therefore established to translate biopolymer-encoded information stereoselectively into sequence- and chain-length specific synthetic polymers.Keywords
This publication has 5 references indexed in Scilit:
- Template-directed ligation: From DNA towards different versatile templatesThe Chemical Record, 2001
- Catalyst for DNA Ligation: Towards a Two-Stage Replication CyclePublished by Wiley ,2000
- Chemical Amplification through Template-Directed SynthesisJournal of the American Chemical Society, 1997
- Enantiomeric Cross-Inhibition in the Synthesis of Oligonucleotides on a Nonchiral TemplateJournal of the American Chemical Society, 1997
- Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic AcidNature, 1953