EXCLUSION OF CHROMOSOMAL MOSAICISM - TABLES OF 90PERCENT, 95PERCENT, AND 99PERCENT CONFIDENCE-LIMITS AND COMMENTS ON USE

Abstract

Tables specifically tailored to the exclusion of cytogenetic mosaicism at 3 confidence levels are presented. The consequences of the assumption of independence in application of the binomial theorem to this question are discussed. The tables are most applicable to the number of cells evaluated from cultures in which all mitoses are arrested in the 1st in vitro division. For long-term cultures the tables are conservatively applicable to the number of separate colonies evaluated. If n cells were evaluated from phytohemagglutinin stimulated peripheral blood after 72 h in cultures, the tables are applicable to between n/2 and n cells.