Clinical Response to Choline plus Piracetam in Senile Dementia: Relation to Red-Cell Choline Levels

Publisher Website
Google Scholar
Abstract
To the Editor: Cognitive impairment is associated with old age, and it becomes especially severe in senile dementia of the Alzheimer's type (SDAT). Several lines of evidence suggest that the memory impairment in SDAT is highly correlated with brain cholinergic dysfunction.1 One important test of the hypothesis that a deficiency in brain cholinergic transmission is related to the loss of memory in SDAT involves examining the effects of enhanced cholinergic function in this disease. Such an approach has been attempted in studies of choline or lecithin treatment in SDAT, with mixed results.2 , 3 Recent experiments in aged rats have shown that . . .