Serum and Tissue Glycoproteins in Mice Bearing Transplantable Tumors.

Abstract

In mice bearing transplantable tumors the serum glycoproteins are increased. Water soluble glycoproteins are also increased in the connective tissue bordering the tumor. This suggests that increased circulating glycoproteins arise from ground substance at the site of invasive growth. The process postulated is one of depolymerization of highly organized, insoluble glycoproteins to smaller, water soluble and diffusible residues.