β-Interferon Plus Inosiplex in the Treatment of Subacute Sclerosing Panencephalitis
- 1 November 1998
- journal article
- other
- Published by SAGE Publications in Journal of Child Neurology
- Vol. 13 (11), 557-559
- https://doi.org/10.1177/088307389801301106
Abstract
We treated seven patients with subacute sclerosing panencephalitis with β-interferon and oral inosiplex for 2 to 15 months. Stabilization or improvement was observed in three patients. The effect of treatment was equivocal in two other patients who became stable. The disease continued its progression in the remaining two patients who died. Treatment shorter than 2 months was not effective. Changes in electroencephalograms (EEG), magnetic resonance images (MRI), or cerebrospinal fluid measles antibody levels did not have a close correlation with clinical course. These results suggest that β-interferon might be efficient in some patients with subacute sclerosing panencephalitis and justify its trial in larger studies with longer follow-up. ( J Child Neurol 1998; 13:557-559).Keywords
This publication has 9 references indexed in Scilit:
- Long-term follow-up of patients with subacute sclerosing panencephalitis treated with intraventricular alpha-interferonNeurology, 1997
- MRI findings in subacute sclerosing panencephalitisNeurology, 1996
- Interferon beta‐lb in the treatment of multiple sclerosisNeurology, 1995
- Combined oral isoprinosine-intraventricular α-interferon therapy for subacute sclerosing panencephalitisBrain & Development, 1993
- Interferon beta in multiple sclerosisNeurology, 1993
- Intraventricular interferon and oral inosiplex in the treatment of subacute sclerosing panencephalitisNeurology, 1992
- Long‐term follow‐up of patients with subacute sclerosing panencephalitis treated with inosiplexAnnals of Neurology, 1982
- The Variable Natural History of Subacute Sclerosing PanencephalitisArchives of Neurology, 1979
- Substantial Spontaneous Long-term Improvement in Subacute Sclerosing PanencephalitisArchives of Neurology, 1978