Hippocampal Pathologic Findings in Schizophrenia
- 1 November 1989
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 46 (11), 1019-1024
- https://doi.org/10.1001/archpsyc.1989.01810110061009
Abstract
• We studied hippocampal sections from 13 schizophrenic patients, 9 nonschizophrenic patients, and 16 normal controls from the Yakovlev brain collection. The three groups were similar in age, gender distribution, and brain weight. Most patients had never received neuroleptics, and the two patient groups had had similar types of leukotomies. We used a semiautomated image analysis system to compute volume and pyramidal-cell density in each of the four sectors of the cornu ammonis, CA1 through CA4, in the right and left hippocampi. Sections from schizophrenic patients had almost consistently the lowest volume and pyramidal-cell density in all sectors. The differences were greatest in left CA4, with schizophrenic patients having significantly lower pyramidal-cell density than normal controls and significantly lower volume than leukotomy controls. Our findings confirm the results of several recent studies showing hippocampal pathologic features in schizophrenia. Our study suggests, however, that the hippocampal neuropathologic findings in schizophrenia may be more subtle and more localized than those reported previously.This publication has 40 references indexed in Scilit:
- Schizophrenia and the BrainNew England Journal of Medicine, 1990
- Limbic pathology in schizophrenia: The entorhinal region—a morphometric studyBiological Psychiatry, 1988
- Is there gliosis in schizophrenia? Investigation of the temporal lobeBiological Psychiatry, 1987
- Cell loss in the hippocampus of schizophrenicsArchiv Fur Psychiatrie Und Nervenkrankheiten, 1986
- Hippocampal pyramidal cells and aging in the human: A quantitative study of neuronal loss in sectors CA1 to CA4Experimental Neurology, 1986
- Prenatal developmental disturbances in the limbic allocortex in schizophrenicsJournal of Neural Transmission, 1986
- Neuropathology of SchizophreniaArchives of General Psychiatry, 1982
- An Anatomy of Schizophrenia?Archives of General Psychiatry, 1973
- Quantitative Brain Measurements in Chronic SchizophreniaThe British Journal of Psychiatry, 1972
- THE PROBLEM OF THE ANATOMY OF SCHIZOPHRENIAJournal of Nervous & Mental Disease, 1930