Levels of Piribedil and its Active Metabolite (S-584) in the Rat Striatum
- 1 January 1975
- journal article
- Published by Taylor & Francis in Xenobiotica
- Vol. 5 (10), 595-600
- https://doi.org/10.3109/00498257509056129
Abstract
1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue. 2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.Keywords
This publication has 11 references indexed in Scilit:
- Effect of piribedil and one of its metabolites on the concentration of homovanillic acid in the rat brainEuropean Journal of Pharmacology, 1974
- Determination of piribedil in biological materials by gas—liquid chromatography—mass fragmentographyJournal of Chromatography A, 1974
- Increase in striatal acetylcholine levels in vivo by piribedil a new dopamine receptor stimulantLife Sciences, 1974
- Effets comparés du Piribédil et de trois de ses métabolites sur le système extrapyramidal du ratCellular and Molecular Life Sciences, 1974
- Stimulation of a dopamine-sensitive adenylate cyclase in homogenates of rat striatum by a metabolite of piribedil (ET 495)Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1974
- ET495 and brain catecholamine mechanisms: Evidence for stimulation of dopamine receptorsEuropean Journal of Pharmacology, 1972
- Dopamine-Sensitive Adenyl Cyclase: Possible Role in Synaptic TransmissionScience, 1971
- Evidence for a new type of dopamine receptor stimulating agentJournal of Pharmacy and Pharmacology, 1971
- Cardiovascular effects of the 1-(2″ pyrimidyl)-4 piperonyl piperazine (ET 495)European Journal of Pharmacology, 1969
- Synthesis and vasodilator activity of new piperazine derivativesJournal of Medicinal Chemistry, 1968