PANTOTHENATE STUDIES II

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Abstract
Conflicting reports have ascribed the antibacterial action of salicylate to various steps in pantothenate metabolism. Studies with pantothenate auxotrophs of Escherichia coli have provided strong evidence that salicylate interferes with pantoate synthesis. In particular, salicylate, in concns. whose inhibiton of the growth of wild type E. coli is reversed by pantoate or pantothenate, does not inhibit the growth of a pantoate auxotroph.