Hydrophobie cluster analysis reveals duplication in the external structure of human α‐interferon receptor and homology with γ‐interferon receptor external domain
- 20 August 1990
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 269 (1), 1-3
- https://doi.org/10.1016/0014-5793(90)81103-u
Abstract
Evidence is presented, based on sequence comparison according to Hydrophobic Cluster Analysis, of a structural and evolutionary relationship between the human α/β-interferon receptor and the human and mouse γ-interferon receptor. These results predict that the human α/β-interferon receptor extracellular part is organised in two homologous subdomains connected by a proline linker. They also predict that both subdomains present some homologies to the external domain of mouse and human γ interferon receptorKeywords
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