Normalization by antipsychotic drugs of biochemically induced abnormal behavior in rats
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 49 (1), 63-68
- https://doi.org/10.1007/bf00427472
Abstract
Male rats were trained to perform a conditioned avoidance response combined with a successive discrimination in a modified shuttle box. The administration of l-Dopa, 100 mg/kg i.p., after inhibition of peripheral aromatic amino acid decarboxylase, or apomorphine, 2 mg/kg i.p., was found to disrupt the discriminative but not the avoidance behavior. The dopamine receptor antagonist pimozide (0.5 mg/kg i.p.), but not the noradrenaline receptor antagonist phenoxybenzamine (10 or 20 mg/kg i.p.) completely antagonized the l-Dopa-induced abnormal behavior, indicating an involvement of central dopamine mechanisms. The present data show that antipsychotic drugs not only inhibit behavior but can also improve behavior in animals with a disturbed function.Keywords
This publication has 19 references indexed in Scilit:
- Different alpha-adrenoreceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agentsNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1976
- Lesions of the nigro-neostriatal dopamine neurons or the bulbo-spinal norepinephrine and 5-hydroxytryptamine neurons in rats: Action of drugsPharmacology & Therapeutics. Part B: General and Systematic Pharmacology, 1975
- Antagonism by haloperidol of the L-DOPA-induced disruption of a successive discrimination in the ratJournal of Neural Transmission, 1975
- Haloperidol-induced disruption of conditioned avoidance responding: Attenuation by prior training or by anticholinergic drugsEuropean Journal of Pharmacology, 1975
- Antagonism by DL-threo-DOPS of the suppression of a conditioned avoidance response induced by a dopamine-?-Hydroxylase inhibitorJournal of Neural Transmission, 1973
- Potentiation of phenothiazines by?-methyltyrosine in treatment of chronic schizophreniaJournal of Neural Transmission, 1972
- Effects of a dopamine (DA)-?-hydroxylase inhibitor on timing behaviourPsychopharmacology, 1972
- Behavioral and biochemical effects ofl-DOPA after peripheral decarboxylase inhibitionBrain Research, 1969
- Peripheral factors in the mediation of the effects of L-dopa on locomotor activityJournal of Pharmacy and Pharmacology, 1969
- Evidence for dopamine receptor stimulation by apomorphineJournal of Pharmacy and Pharmacology, 1967