Phospholipase A2 Hydrolysis of Mixed Phospholipid Vesicles Formed on Polyelectrolyte Hollow Capsules
- 28 May 2003
- journal article
- research article
- Published by Wiley in Chemistry – A European Journal
- Vol. 9 (11), 2589-2594
- https://doi.org/10.1002/chem.200304315
Abstract
Mixtures of the phospholipids L-α-dimyristoylphosphatidic acid (DMPA) and L-α-dipalmitoylphosphatidylcholine (DPPC) have been successfully adsorbed onto the charged surface of multilayer polyelectrolyte capsules to form a novel vesicle. Leaving such vesicles in phospholipase A2 solution, we observed the hydrolysis reaction on the surface of the lipid/polymer vesicles and a permeability change before and after the reaction by confocal-laser scanning microscopy (CLSM). A capsule with adjustable permeability was constructed. This method may provide new features for drug-release vesicles.Keywords
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