Alkaloids fromRauwolfia cubanaStem Bark

Abstract

Six indole alkaloids, tetrahydroalstonine, aricine, 16-epi-affinine, ajmaline, amerovolfine, and amerovolficine have been isolated from the ethanolic extract of the stem bark of Rauwolfia cubana A. DC. Amerovolfine (N ^α-demethylaccedine) and amerovolficine (16-demethoxy-carbonylpagicerine) are new alkaloids related to 16-epi-affinine, and their structures have been determined by spectroscopic analysis.