Effect of Hyperthyroidism on Distribution of Adenosine Phosphates and Glycogen in Liver.

Abstract
Chronic hyperthyroidism induced in guinea pigs by daily injection of thyroxin has no effect on concentrations of ATP, ADP, and AMP in the liver. This finding gives no support to the postulate that thyroxine produces its metabolic effects by dissociating phosphorylation from oxidation. Reduction in glycogen content of liver that results from chronic hyperthyroidism is entirely in the fraction extractable by TCA.