Study of the Lipophilic Character of Xanthine and Adenosine Derivatives: II. Relationships Between Log K', RMand Log P Values
- 1 March 1990
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 13 (5), 913-927
- https://doi.org/10.1080/01483919008049221
Abstract
The log k' values of a series of xanthine and adenosine derivatives were measured by means of a reversed-phase HPLC. The HPLC data were shown to be well correlated with previously reported RM and RMC18 values. The equations describing the relationships log k'/RM and log k'/RMC18 allowed the calculation of the log k' values of some compounds, which were not tested in the HPLC system. Since the relationship log k'/log P is very close to the previously described relationships RM/log P and RMC18/log P one can conclude that reversed-phase TLC and HPLC are very similar in describing the lipophilicity of the compounds.This publication has 5 references indexed in Scilit:
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