Early Assessment of Myocardial Salvage by Contrast-Enhanced Magnetic Resonance Imaging
- 3 October 2000
- journal article
- other
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 102 (14), 1678-1683
- https://doi.org/10.1161/01.cir.102.14.1678
Abstract
Background —Myocardial salvage after acute myocardial infarction is defined clinically by early restoration of flow and long-term improvement in contractile function. We hypothesized that contrast-enhanced magnetic resonance imaging (MRI), performed early after myocardial infarction, indexes myocardial salvage. We studied the relationship between the transmural extent of hyperenhancement by contrast-enhanced MRI, restoration of flow, and recovery of function. Methods and Results —The left anterior descending coronary artery was occluded in dogs (n=15) for either 45 minutes, 90 minutes, or permanently. Cine and contrast-enhanced MRI were performed 3 days after the procedure; cine MRI was also done 10 and 28 days after the procedure. The transmural extent of hyperenhancement and wall thickening were determined using a 60-segment model. The mean transmural extent of hyperenhancement for the 45-minute occlusion group was 22% of the 90-minute group and 18% of the permanent occlusion group ( P P P Conclusions —A reduction in the transmural extent of hyperenhancement by contrast-enhanced MRI early after myocardial infarction is associated with an early restoration of flow and future improvement in contractile function.Keywords
This publication has 6 references indexed in Scilit:
- TRIAL OF TISSUE PLASMINOGEN ACTIVATOR FOR MORTALITY REDUCTION IN ACUTE MYOCARDIAL INFARCTIONThe Lancet, 1988
- The Western Washington Randomized Trial of Intracoronary Streptokinase in Acute Myocardial InfarctionNew England Journal of Medicine, 1985
- Dissociation between two-dimensional echocardiographic left ventricular wall motion and myocardial salvage in early experimental acute myocardial infarction in dogsThe American Journal of Cardiology, 1984
- Myocardial protection by collateral vessels during experimental coronary ligation: A prospective study in a canine two-infarction modelBasic Research in Cardiology, 1984
- Response of reperfusion-salvaged, stunned myocardium to inotropic stimulationAmerican Heart Journal, 1984
- Basic principles of ROC analysisSeminars in Nuclear Medicine, 1978