New antitumour bicyclic hexapeptides, RA-IX and -X from Rubia cordifolia. Part 3. Conformation–antitumour activity relationship
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 4,p. 455-459
- https://doi.org/10.1039/p19920000455
Abstract
RA-IX and -X, new antitumour bicyclic hexapeptides were isolated from Rubia cordifolia and their structures were elucidated by spectroscopic and chemical evidences. RA-X containing a glutamic acid at residue 2 showed strong antitumour activity. However, RA-IX with conformation restricted to a type II β-turn at residues 2 and 3 showed almost no antitumour activity. Their conformation–antitumour activity relationships are discussed.This publication has 20 references indexed in Scilit:
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