The structure of the chromatin core particle in solution
Open Access
- 1 September 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 4 (9), 3199-3214
- https://doi.org/10.1093/nar/4.9.3199
Abstract
The shape and size of the nucleosomal core particle from chromatin has been examined by analysis of neutron and X-ray scattering data from dilute solutions. Calculations of scattering for many different models have been made and only one model was able to account for both the X-ray and neutron profiles. This model is an oblate structure with height about 50Å and diameter 110Å. The DNA is mainly confined to two annuli located at the top and bottom respectively of the core particle positioned on the outside of a compact protein core which has a height of about 40Å and diameter about 73Å.Keywords
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