Simultaneous autoradiographic and immunohistochemical localization of estrogen and gonadotropin in the rat pituitary

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Abstract
A combined autoradiographic and immunohistochemical technique is introduced which is suitable to simultaneously localize hypophyseal sites of nuclear (3H)-estradiol uptake and anti-hCG-characterized “gonadotropes”. Most, but not all, “gonadotropes” show significant nuclear concentration of radioactivity. A large percentage of non-“gonadotropes” also show nuclear uptake of label.