The different roles of serum and calcium in the control of proliferation of BALB/C 3T3 mouse cells
- 1 February 1976
- journal article
- Published by Springer Nature in In Vitro Cellular & Developmental Biology - Plant
- Vol. 12 (2), 120-123
- https://doi.org/10.1007/bf02796358
Abstract
Proliferatively inactive BALB/c 3T3 mouse cells in dense cultures initiate a growth-division cycle upon exposure to fresh calf serum in a low-calcium (0.01 µM) medium. If these calcium-deprived cells are not supplied with calcium sometime during the first 10 hours after serum stimulation, they will rapidly return to a proliferatively inactive state without initiating DNA synthesis. The prereplicative development of such stimulated calcium-deprived cells appears to stop at an advanced stage, because addition of calcium as late as 10 hours after serum exposure rapidly initiates DNA synthesis, and enables the culture’s DNA-synthetic activity subsequently to reach its peak value at the same time as in control cultures.Keywords
This publication has 23 references indexed in Scilit:
- The control of liver regeneration by parathyroid hormone and CalciumJournal of Cellular Physiology, 1976
- Regulation by calcium of the proliferation of heart cells from young adult ratsIn Vitro Cellular & Developmental Biology - Plant, 1976
- The positive control of cell proliferation by the interplay of calcium ions and cyclic nucleotides. A reviewIn Vitro Cellular & Developmental Biology - Plant, 1976
- Failure of tritiated thymidine incorporation into DNA to reflect the autoradiographically demonstrable calcium‐induced increase in thymic lymphoblast DNA synthesisJournal of Cellular Physiology, 1975
- Cyclic AMP stimulation of calcium efflux from kidney, liver, and heart mitochondriaThe Journal of Membrane Biology, 1974
- Calcium‐dependent stimulation by a phorbol ester (PMA) of thymic lymphoblast DNA synthesis and proliferationJournal of Cellular Physiology, 1973
- Adrenergic antagonists, and a possible link between the increase in cyclic adenosine 3′,5′‐monophosphate and DNA synthesis during liver regenerationJournal of Cellular Physiology, 1973
- Requirement for calcium ions in lymphocyte transformation stimulated by phytohemagglutininJournal of Cellular Physiology, 1972
- The roles of calcium and cyclic AMP in the stimulatory action of parathyroid hormone on thymic lymphocyte proliferationJournal of Cellular Physiology, 1971
- Energy‐Linked Ion Movements in Mitochondrial SystemsPublished by Wiley ,1967