Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells
Open Access
- 15 August 2006
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 108 (4), 1284-1290
- https://doi.org/10.1182/blood-2005-12-4821
Abstract
Newborns are prone to microbial infection and have poor memory responses to multiple antigens. We have previously shown that human neonatal blood monKeywords
This publication has 47 references indexed in Scilit:
- Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNAImmunity, 2005
- Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependentCellular Microbiology, 2005
- Toll-like receptor signallingNature Reviews Immunology, 2004
- A Defect in Nucleosome Remodeling Prevents IL-12(p35) Gene Transcription in Neonatal Dendritic CellsThe Journal of Experimental Medicine, 2004
- Defective macrophage function in neonates and its impact on unresponsiveness of neonates to polysaccharide antigensJournal of Leukocyte Biology, 2004
- The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamilyEuropean Journal of Immunology, 2003
- Bruton's Tyrosine Kinase Is a Toll/Interleukin-1 Receptor Domain-binding Protein That Participates in Nuclear Factor κB Activation by Toll-like Receptor 4Journal of Biological Chemistry, 2003
- Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848Nature Immunology, 2002
- Innate Immune RecognitionAnnual Review of Immunology, 2002
- CD40 AND CD154 IN CELL-MEDIATED IMMUNITYAnnual Review of Immunology, 1998