A Short and Economical Synthesis of 2,2,7,7-Tetramethyl-4-Octene -3,6-dione from 2-Furoic Acid and t-Butyl Chloride

Abstract

2,2,7,7-Tetramethyl-4-octene-3,6-dione (5), a useful synthetic intermediate, 1was required in kilogram quantities for further structural elaboration. Previous synthesis of (5) have given low yields ² or have required unstable, ³ lachrymatory ⁴ or prohibitively expensive ⁵ intermediates. (5) has now been prepared in 43% overall yield by a route well suited to large scale operation (scheme)