Physiological Evidence of a Site of Action of DDT in an Insect

Abstract

Injn. of DDT into a site (or sites) common to the leg and body of the roach, Periplaneta americana, produced typical DDT contractions and tremors. It was strongly indicated that these sites consisted of that region of a nerve lying between the origin of its fibers in the leg exclusive of the origin and the endings, i.e., the myo-neural junctions, of the fibers. The DDT action affected the nerves somewhere along their lengths whereas nicotine affected the ganglia.