Sequence of a Placental cDNA Encoding the Mouse Insulin-Like Growth Factor II Precursor
- 1 October 1986
- journal article
- research article
- Published by Mary Ann Liebert Inc in DNA
- Vol. 5 (5), 357-361
- https://doi.org/10.1089/dna.1986.5.357
Abstract
CDNAs encoding the mouse insulin-like growth factor II (IGF-II) precursor have been isolated from a placental library and sequenced. Mouse prepro-IGF-II is predicted to be 180 amino acids and has 84% and 97% identity with human and rat IGF-II precursors, respectively. There are two prepro-IGF-II transcripts in mouse placenta; the major transcript is 3850 bases and the minor one is 4800 bases. Prepro-IGF-II mRNA cannot be detected in adult mouse liver, but it is readily detected in adult human liver, indicating that there are differences in the regulation of expression of the IGF-II gene in the liver of adult mice and human beings.This publication has 22 references indexed in Scilit:
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