Proposal for the biologically active conformation of opiates and enkephalin.
- 1 November 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (11), 5179-5183
- https://doi.org/10.1073/pnas.74.11.5179
Abstract
A model [neuroblastoma .times. glioma] for the opiate receptor was defined by using a computer-based molecular display and X-ray crystallographic input data. The model could explain the stereochemical fashion in which the morphine, morphinan and oripavine classes of compounds interact with the receptor. The minimal structural unit of the enkephalins demonstrated to be pharmacologically active, Tyr-Gly-Gly-Phe, was also fitted to this model by using a systematic search of conformational space.This publication has 27 references indexed in Scilit:
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